原发性高血压患者血小板中血清素的动力学

Kinetics of serotonin in platelets in essential hypertension.

作者信息

Nityanand S, Tekwani B L, Chandra M, Shanker K, Singh B N

机构信息

Department of Medicine, King George's Medical College, Lucknow, India.

出版信息

Life Sci. 1990;46(5):367-72. doi: 10.1016/0024-3205(90)90016-k.

DOI:10.1016/0024-3205(90)90016-k

PMID:1689448

Abstract

In a study of the kinetics of 5-hydroxytryptamine (5-HT) in platelets in 26 hypertensive subjects with a mean systolic and diastolic blood pressure of 153.9 +/- 26.9 and 106.9 +/- 9.1 mm Hg respectively, it has been observed that in hypertensive platelets there was a marked decrease in 5-HT uptake and content, an increase in 5-HT efflux and an accompanying increase in Plasma 5-HT and 5-HIAA levels. Regression analysis of the data indicated a significant correlation between rise in diastolic blood pressure and these changes in 5-HT kinetics.

摘要

在一项针对26名高血压患者血小板中5-羟色胺（5-HT）动力学的研究中，这些患者的平均收缩压和舒张压分别为153.9±26.9毫米汞柱和106.9±9.1毫米汞柱。研究观察到，高血压患者的血小板中5-HT摄取和含量显著降低，5-HT流出增加，同时血浆5-HT和5-羟吲哚乙酸（5-HIAA）水平升高。数据的回归分析表明，舒张压升高与这些5-HT动力学变化之间存在显著相关性。