Wheeler C A, Davis S, Degefu S, Thorneycroft I H, O'Quinn A G
Department of Obstetrics and Gynecology, Tulane University School of Medicine, New Orleans, Louisiana.
Obstet Gynecol. 1990 Mar;75(3 Pt 2):547-9.
Ovarian choriocarcinoma is difficult to diagnose in the reproductive-age patient. A case of nongestational ovarian choriocarcinoma is discussed which presented like a molar pregnancy initially. Because of falsely low beta-hCG values (283 mIU/L) caused by the high-dose "hook effect" in the double antibody immunoassay system, however, a diagnosis of ectopic pregnancy was entertained. At laparotomy, a large necrotic ovarian choriocarcinoma was found along with large theca lutein cysts. The hook effect may mislead the clinician, and it is important to recognize this effect to avoid misdiagnosis.
卵巢绒毛膜癌在育龄期患者中难以诊断。本文讨论了一例非妊娠性卵巢绒毛膜癌病例，该病例最初表现类似葡萄胎。然而，由于在双抗体免疫分析系统中高剂量“钩状效应”导致β-hCG值假性降低（283 mIU/L），曾考虑诊断为异位妊娠。剖腹探查时，发现一个巨大的坏死性卵巢绒毛膜癌以及大的黄素囊肿。钩状效应可能会误导临床医生，认识到这种效应对于避免误诊很重要。
