de Crombrugghe B, Vuorio T, Karsenty G
Department of Molecular Genetics, University of Texas, M.D. Anderson Cancer Center, Houston.
Rheum Dis Clin North Am. 1990 Feb;16(1):109-23.
Increased gene transcription is a mechanism responsible for the exaggerated accumulation of type I and III collagens in scleroderma and other fibrotic syndromes. We review recent studies on the mechanisms that control transcription of the alpha 1 (I) and alpha 2 (I) collagen genes. Several specific DNA binding proteins have been identified which either activate or inhibit transcription of these genes. It is probable that the complexity of transcription factors that control the type I collagen genes corresponds to a multiplicity of cytokines and other hormonal effectors, which influence the expression of these genes by binding to specific receptors and by activating intracellular signaling pathways.
基因转录增加是硬皮病和其他纤维化综合征中I型和III型胶原蛋白过度积累的一种机制。我们综述了最近关于控制α1（I）和α2（I）胶原蛋白基因转录机制的研究。已经鉴定出几种特异性DNA结合蛋白，它们要么激活要么抑制这些基因的转录。控制I型胶原蛋白基因的转录因子的复杂性可能对应于多种细胞因子和其他激素效应物，这些效应物通过与特异性受体结合并激活细胞内信号通路来影响这些基因的表达。
