Mohanna Salim, Maco Vicente, Gown Allen, Morales Domingo, Bravo Francisco, Gotuzzo Eduardo
Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru.
Am J Trop Med Hyg. 2006 Aug;75(2):324-6.
Kaposi's sarcoma (KS) has been classified in four clinical variants (classic or Mediterranean; endemic or African; epidemic or AIDS-related; iatrogenic or immunosuppression-related). Human herpesvirus 8 (HHV-8), has been found in all these variants. We herein discuss the unusual presentation of a 53-year-old indigenous patient with purplish-brown nodular lesions on lower extremities, and miliary tuberculosis. ELISA-HIV tests were negative and immunohistochemistry (IHC) of the tumor tissue was positive for HHV-8. This is the first reported case in which the presence of HHV-8 was evidenced by means of IHC techniques in Peru. We also review all available Peruvian literature of classic KS, a disease that has been frequently reported in indigenous population of Peru since 1968, making this country a possible endemic zone of classic KS.
卡波西肉瘤（KS）已被分为四种临床变体（经典型或地中海型；地方性或非洲型；流行性或艾滋病相关型；医源性或免疫抑制相关型）。在所有这些变体中均发现了人类疱疹病毒8（HHV-8）。我们在此讨论一名53岁的本土患者的不寻常表现，该患者下肢有紫褐色结节性病变，并患有粟粒性肺结核。酶联免疫吸附测定法（ELISA）检测HIV呈阴性，肿瘤组织的免疫组织化学（IHC）检测显示HHV-8呈阳性。这是秘鲁首例通过免疫组织化学技术证实存在HHV-8的报告病例。我们还回顾了所有现有的关于经典型KS的秘鲁文献，自1968年以来，这种疾病在秘鲁的本土人群中经常被报道，这使得该国可能是经典型KS的一个地方性流行区。
