Fungal metabolic model for tyrosinemia type 3: molecular characterization of a gene encoding a 4-hydroxy-phenyl pyruvate dioxygenase from Aspergillus nidulans.
作者信息
da Silva Ferreira Márcia Eliana, Savoldi Marcela, Sueli Bonato Pierina, Goldman Maria Helena S, Goldman Gustavo H
机构信息
Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil.
出版信息
Eukaryot Cell. 2006 Aug;5(8):1441-5. doi: 10.1128/EC.00160-06.
Abstract
Mutations in the human HPD gene (encoding 4-hydroxyphenylpyruvic acid dioxygenase) cause hereditary tyrosinemia type 3 (HT3). We deleted the Aspergillus nidulans homologue (hpdA). We showed that the mutant strain is not able to grow in the presence of phenylalanine and that it accumulates increased concentrations of tyrosine and 4-hydroxyphenylpyruvic acid, mimicking the human HT3 phenotype.
摘要
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