Masadome Takashi, Yada Kensuke, Wakida Shin-ichi
Department of Applied Chemistry, Faculty of Engineering, Shibaura Institute of Technology, Tokyo, Japan.
Anal Sci. 2006 Aug;22(8):1065-9. doi: 10.2116/analsci.22.1065.
A cationic surfactant ion-selective field-effect transistor (cationic surfactant-ISFET) has been developed based on the tetraphenylborate derivative known as sodium tetrakis[3,5-bis(trifluoromethyl)phenyl]borate. The cationic surfactant-ISFET shows an almost Nernstian response to tetradecyldimethylbenzylammonium chloride (Zephiramine) over a concentration range between 1.0 x 10(-6) M and 1.0 x 10(-3) M, with a slope of 58.5 +/- 1.7 mV/decade. The cationic surfactant-ISFET can be used over a range of pH values, between pH 3 and 9. The cationic surfactant-ISFET shows excellent selectivity for Zephiramine over small inorganic cations, but shows similar selectivity for other cationic surfactants, such as hexadecyltrimethylammonium and stearyltrimethylammonium ions. A microfluidic polymer chip was integrated with the cationic surfactant-ISFET, and this was fabricated using polystyrene plates and stainless wires as a template for the channel. Cationic surfactant-ISFETs used in a batch system and microchips integrated with cationic surfactant-ISFETs showed very similar performance in terms of low detection limits, slope sensitivity and the stability of the potential response. The microfluidic polymer chip was then applied to the determination of cationic surfactants in dental rinses.
基于被称为四[3,5-双（三氟甲基）苯基]硼酸钠的四苯基硼酸盐衍生物，开发了一种阳离子表面活性剂离子选择性场效应晶体管（阳离子表面活性剂离子敏感场效应晶体管）。阳离子表面活性剂离子敏感场效应晶体管在1.0×10⁻⁶ M至1.0×10⁻³ M的浓度范围内对十四烷基二甲基苄基氯化铵（新洁尔灭）表现出几乎能斯特响应，斜率为58.5±1.7 mV/十倍浓度变化。阳离子表面活性剂离子敏感场效应晶体管可在pH值3至9的范围内使用。阳离子表面活性剂离子敏感场效应晶体管对新洁尔灭相对于小无机阳离子表现出优异的选择性，但对其他阳离子表面活性剂，如十六烷基三甲基铵和硬脂基三甲基铵离子表现出相似的选择性。将微流控聚合物芯片与阳离子表面活性剂离子敏感场效应晶体管集成，该芯片使用聚苯乙烯板和不锈钢丝作为通道模板制造。在批处理系统中使用的阳离子表面活性剂离子敏感场效应晶体管以及与阳离子表面活性剂离子敏感场效应晶体管集成的微芯片在低检测限、斜率灵敏度和电位响应稳定性方面表现出非常相似的性能。然后将微流控聚合物芯片应用于漱口水阳离子表面活性剂的测定。
