Shulman R M, Geraghty T J, Tadros M
Spinal Injuries Unit, Princess Alexandra Hospital, Qld, Australia.
Spinal Cord. 2007 Apr;45(4):314-7. doi: 10.1038/sj.sc.3101962. Epub 2006 Aug 8.
Case report.
Examine an unusual drug related case of myeloneuropathy as well as the pathophysiology of nitrous oxide induced subacute combined degeneration.
Major metropolitan teaching hospital - Princess Alexandra Hospital, Queensland, Australia.
Review case notes, investigations, relevant medical literature and epidemiological data.
A 23-year-old female developed a myeloneuropathy and encephalopathy after an 8-month history of nitrous oxide abuse. Her presentation was complicated by acute renal failure, deep vein thrombosis (DVT) and pulmonary embolism (PE) as well as severe cognitive deficits. After eight months of multidisciplinary rehabilitation the patient is able to walk short distances with mobility aids and is able to manage self cares. However, she still requires a wheelchair for long distances and will have significant residual neurological deficits.
The abuse of nitrous oxide has potentially serious outcomes that require discussion of issues related to harm minimisation and health promotion.
病例报告。
研究一例罕见的与药物相关的脊髓神经病病例以及一氧化二氮所致亚急性联合变性的病理生理学。
澳大利亚昆士兰州的一家大型都市教学医院——亚历山德拉公主医院。
查阅病例记录、检查结果、相关医学文献和流行病学数据。
一名23岁女性在有8个月一氧化二氮滥用史后出现脊髓神经病和脑病。她的病情因急性肾衰竭、深静脉血栓形成（DVT）和肺栓塞（PE）以及严重认知缺陷而复杂化。经过8个月的多学科康复治疗，患者能够借助移动辅助工具短距离行走，并能够自理。然而，她长途仍需要轮椅，并且将有明显的残余神经功能缺损。
一氧化二氮滥用可能产生严重后果，这需要对与危害最小化和健康促进相关的问题进行讨论。
