后期促进复合物/细胞周期体：一台旨在破坏的机器。

The anaphase promoting complex/cyclosome: a machine designed to destroy.

作者信息

Peters Jan-Michael

机构信息

Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria.

出版信息

Nat Rev Mol Cell Biol. 2006 Sep;7(9):644-56. doi: 10.1038/nrm1988. Epub 2006 Aug 9.

DOI:10.1038/nrm1988

PMID:16896351

Abstract

The anaphase promoting complex/cyclosome (APC/C) is a ubiquitin ligase that has essential functions in and outside the eukaryotic cell cycle. It is the most complex molecular machine that is known to catalyse ubiquitylation reactions, and it contains more than a dozen subunits that assemble into a large 1.5-MDa complex. Recent discoveries have revealed an unexpected multitude of mechanisms that control APC/C activity, and have provided a first insight into how this unusual ubiquitin ligase recognizes its substrates.

摘要

后期促进复合物/细胞周期体（APC/C）是一种泛素连接酶，在真核细胞周期内外均具有重要功能。它是已知催化泛素化反应的最复杂分子机器，包含十几个亚基，组装成一个1.5兆道尔顿的大型复合物。最近的发现揭示了控制APC/C活性的众多意外机制，并首次深入了解了这种不同寻常的泛素连接酶如何识别其底物。