通过糖基衍生的2,3-环氧醇的串联脱苄环化反应立体选择性合成高度O-官能化的对映体纯2,3,4-三取代四氢呋喃。
Stereoselective synthesis of highly O-functionalized enantiopure 2,3,4-trisubstituted tetrahydrofurans by tandem debenzylative cyclization of glycal derived 2,3-epoxy alcohols.
作者信息
Reddy L Vijaya Raghava, Roy Abhijeet Deb, Roy Raja, Shaw Arun K
机构信息
Division of Medicinal and Process Chemistry, Central Drug Research Institute (CDRI), Lucknow 226001, India.
出版信息
Chem Commun (Camb). 2006 Aug 28(32):3444-6. doi: 10.1039/b606519h. Epub 2006 Jul 10.
DOI:10.1039/b606519h
PMID:16896489
Abstract
A new and highly efficient methodology for the construction of synthetically important highly O-functionalized enantiopure 2,3,4-trisubstituted tetrahydrofurans with three contiguous stereocenters is reported.
摘要
报道了一种用于构建具有三个相邻立体中心的合成重要的高度O-官能化对映体纯2,3,4-三取代四氢呋喃的全新且高效的方法。
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