Perret P Cecilia
Unidad de Infectología, Departamento de Pediatría, Facultad de Medicina, Pontificia Universidad Católica de Chile, Chile.
Rev Chilena Infectol. 2006 Sep;23(3):257-60. doi: 10.4067/s0716-10182006000300011. Epub 2006 Aug 4.
After the introduction of the pertussis vaccine the number of cases decreased substantially, albeit, the disease remains present affecting mostly young infants in whom it causes severe complications, adolescents and adults. Adults are the main reservoir of Bordetella pertussis and serve as vehicle of transmission reservoir to infants. The new pertussis vaccines, manufactured for adolescents and adults, have good immunogenicity, safety and efficacy (92%) profile. The introduction of this vaccine into a universal vaccination program for adolescents and adults, would decrease the incidence of the disease in this population and more importantly, transmission of the microorganism to infants.
百日咳疫苗引入后，病例数大幅下降，尽管如此，该疾病仍然存在，主要影响易引发严重并发症的幼儿、青少年和成年人。成年人是百日咳博德特氏菌的主要储存宿主，并作为向婴儿传播的载体。为青少年和成年人生产的新型百日咳疫苗具有良好的免疫原性、安全性和有效性（92%）。将这种疫苗纳入青少年和成年人的通用疫苗接种计划，将降低该人群中疾病的发病率，更重要的是，减少微生物向婴儿的传播。
