4-溴哒嗪-3,6-二酮在构建3-氨基哒嗪文库中的应用。
Use of 4-bromo pyridazine 3,6-dione for building 3-amino pyridazine libraries.
作者信息
Schmitt Martine, de Araújo-Júnior João X, Oumouch Said, Bourguignon Jean-Jacques
机构信息
Laboratoire de Pharmacochimie de la Communication Cellulaire (UMR 7081), Faculté de Pharmacie, Université Louis Pasteur, Illkirch cedex, France.
出版信息
Mol Divers. 2006 Aug;10(3):429-34. doi: 10.1007/s11030-006-9020-x. Epub 2006 Jul 29.
PMID:16896543
Abstract
An efficient method for preparation of 4,6 or 5,6 disubstituted 3-aminopyridazines was easily carried out starting from easily available 4-bromo-pyridazine-3,6-dione, and using combination of both amination and Pd(0) cross-coupling reactions under microwave irradiation.
摘要
一种制备4,6或5,6二取代3-氨基哒嗪的有效方法可以很容易地从容易获得的4-溴哒嗪-3,6-二酮开始，并在微波辐射下使用胺化反应和Pd(0)交叉偶联反应的组合来进行。
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