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粥样硬化性肾动脉狭窄的冠状动脉样血运重建术——181例连续患者的结果

Coronary-like revascularization for atherosclerotic renal artery stenosis--results in 181 consecutive patients.

作者信息

Lanzer P, Weser R, Prettin C

机构信息

Klinik für Innere Medizin, Gesundheitszentrum Bitterfeld/Wolfen, 06749, Bitterfeld, Germany.

出版信息

Clin Res Cardiol. 2006 Nov;95(11):584-90. doi: 10.1007/s00392-006-0429-0. Epub 2006 Aug 16.

Abstract

AIMS

The aim of this study was to document the early outcome of coronary-like revascularization for atherosclerotic renal artery stenosis (ARAS).

METHODS AND RESULTS

A total of 181 consecutive patient, 102 men, mean age 66.1 (+/- 9.2) years and 79 females, mean age 68.4 (+/- 9.2) years and 198 lesions were treated between February 1999 and May 2004 for ARAS and retrospectively analyzed. At least one major cardiovascular risk factor was present in 179 (98.9%) patients. Pre-dilatation ARAS was 81.3+/-9.6%, 27 ARAS were 50-70% and no ARAS was <50%. 135 (68.2%) of the ARAS lesions were ostial and 63 (31.8%) were non-ostial. In 17 (9.4%) patients bilateral ARAS were present. Technical success defined as residual stenosis < or =30% was achieved in 178 (98.3%) of patients and 195 (98.5%) of lesions. In one patient (0.5%) the target ARAS could not be crossed, in two (1.1%) patients residual stenosis was >30%. No major adverse cardiac or cerebral effects were observed. In 3.9% of patients minor local complications of the access site occurred; 4 (2.2%) inguinal hematoma, 3 (1.7%) pseudoaneurysm were documented. Serum creatinine concentrations and systolic and diastolic blood pressure before and after the intervention were not statistically different.

CONCLUSIONS

Coronary-like approach to ARAS revascularization is technically feasible and associated with a very low complication rate.

摘要

目的

本研究旨在记录动脉粥样硬化性肾动脉狭窄(ARAS)冠状动脉样血管重建术的早期结果。

方法与结果

1999年2月至2004年5月期间,共连续治疗了181例患者,其中男性102例,平均年龄66.1(±9.2)岁,女性79例,平均年龄68.4(±9.2)岁,共治疗198处病变,并进行回顾性分析。179例(98.9%)患者存在至少一种主要心血管危险因素。预扩张时ARAS为81.3±9.6%,27处ARAS为50-70%,无ARAS<50%。135处(68.2%)ARAS病变位于开口处,63处(31.8%)位于非开口处。17例(9.4%)患者存在双侧ARAS。178例(98.3%)患者和195处(98.5%)病变实现了技术成功,定义为残余狭窄≤30%。1例患者(0.5%)未能穿过目标ARAS,2例患者(1.1%)残余狭窄>30%。未观察到重大不良心脏或脑部影响。3.9%的患者出现了轻微的穿刺部位局部并发症;记录到4例(2.2%)腹股沟血肿,3例(1.7%)假性动脉瘤。干预前后血清肌酐浓度以及收缩压和舒张压无统计学差异。

结论

冠状动脉样方法进行ARAS血管重建术在技术上是可行的,且并发症发生率非常低。

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