环孢素A对主动诱导和被动转移的实验性变应性神经炎的抑制作用

Suppression of actively induced and passively transferred experimental allergic neuritis by cyclosporin A.

作者信息

Nakayasu H, Ota K, Tanaka H, Irie H, Takahashi K

机构信息

Institute of Neurological Sciences, Tottori University School of Medicine, Yonago, Japan.

出版信息

J Neuroimmunol. 1990 Mar;26(3):219-27. doi: 10.1016/0165-5728(90)90004-7.

DOI:10.1016/0165-5728(90)90004-7

PMID:1689744

Abstract

The effect of cyclosporin A (CyA) on experimental allergic neuritis (EAN) was examined. CyA suppressed the development of actively induced EAN. The earlier treatment with CyA was begun, the more effective was its effect. CyA was effective even after the development of clinical signs. In actively induced EAN, cessation of CyA treatment lead to the development of EAN. However, in passively induced EAN, it did not. We could not find any differences in the distribution of infiltrating T cell subsets between the control group and the CyA-treated group.

摘要

研究了环孢素A（CyA）对实验性变应性神经炎（EAN）的影响。CyA抑制主动诱导的EAN的发展。CyA治疗开始得越早，其效果越有效。即使在临床症状出现后，CyA仍有效。在主动诱导的EAN中，停止CyA治疗会导致EAN的发展。然而，在被动诱导的EAN中，情况并非如此。我们未发现对照组和CyA治疗组之间浸润性T细胞亚群的分布有任何差异。