Melzer Werner, Andronache Zoita, Ursu Daniel
Department of Applied Physiology, University of Ulm, Albert-Einstein-Allee 11, D-89069, Ulm, Germany.
J Muscle Res Cell Motil. 2006;27(5-7):307-14. doi: 10.1007/s10974-006-9093-2. Epub 2006 Aug 9.
In excitation-contraction coupling (EC coupling) of skeletal muscle, large and rapid changes of the myoplasmic Ca2+ concentration mediate the activation and termination of force. The L-type Ca2+ channel (dihydropyridine receptor, DHP receptor) is a central component of the EC coupling process. Its predominant role is to provide the Ca2+ release channels of the sarcoplasmic reticulum (SR) with the sensitivity to cell membrane voltage. The DHP receptor consists of five different proteins (alpha1S, beta1, gamma1, delta and alpha2) whose tasks and functional characteristics are still incompletely understood. This short review summarizes progress made in studying the physiology of the gamma1 subunit, a membrane polypeptide that is highly specific for skeletal muscle. The focus is on recent results obtained from muscle of gamma1-deficient mice.
在骨骼肌的兴奋-收缩偶联（EC 偶联）过程中，肌浆内 Ca2+浓度的大幅快速变化介导了力量的激活与终止。L 型 Ca2+通道（二氢吡啶受体，DHP 受体）是 EC 偶联过程的核心组成部分。其主要作用是使肌浆网（SR）的 Ca2+释放通道对细胞膜电压产生敏感性。DHP 受体由五种不同的蛋白质（α1S、β1、γ1、δ 和 α2）组成，其功能和特性尚未完全明确。这篇简短的综述总结了在研究 γ1 亚基生理学方面取得的进展，γ1 亚基是一种对骨骼肌具有高度特异性的膜多肽。重点是来自 γ1 基因缺失小鼠肌肉的最新研究结果。
