Schwartz K, Nachman R, Yossifoff M, Sapir R, Weizman A, Rehavi M
Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel.
J Neural Transm (Vienna). 2007;114(4):427-30. doi: 10.1007/s00702-006-0549-8. Epub 2006 Aug 8.
We compared the effect of 5 days D-amphetamine (5 mg/kg/day i.p.) and cocaine (15 mg/kg/day i.p.) administration on the vesicular monoamine transporter 2 (VMAT2) density in rat brain. VMAT2 expression was assessed by [(3)H]dihydrotetrabenazine high affinity binding. Cocaine administration led to significant increases in VMAT2 density in both prefrontal cortex (+40%, p < 0.01) and striatum (+23%, p < 0.05), while amphetamine did not affect VMAT2 expression. The upregulation of VMAT2 may serve as compensatory mechanism aimed to enhance the vesicular monoamine storage capacity.
我们比较了连续5天腹腔注射D-苯丙胺（5毫克/千克/天）和可卡因（15毫克/千克/天）对大鼠脑内囊泡单胺转运体2（VMAT2）密度的影响。通过[³H]二氢四苯嗪高亲和力结合来评估VMAT2的表达。给予可卡因导致前额叶皮质（增加40%，p < 0.01）和纹状体（增加23%，p < 0.05）的VMAT2密度显著增加，而苯丙胺不影响VMAT2的表达。VMAT2的上调可能是一种旨在增强囊泡单胺储存能力的补偿机制。
