Jin Fengyi, Prestage Garrett P, Mao Limin, Kippax Susan C, Pell Catherine M, Donovan Basil, Templeton David J, Taylor Janette, Mindel Adrian, Kaldor John M, Grulich Andrew E
National Centre in HIV Epidemiology and Clinical Research, Darlinghurst, NSW 2010, Australia.
J Infect Dis. 2006 Sep 1;194(5):561-70. doi: 10.1086/506455. Epub 2006 Jul 28.
Despite increasing reports of herpes simplex virus (HSV) type 1 (HSV-1)-associated anogenital herpes, there are very limited data comparing the seroepidemiological profile of and risk factors for HSV-1 and HSV type 2 (HSV-2) infection.
Sexual behaviors were examined as risk factors for prevalent and incident HSV-1 and HSV-2 infections in a community-based cohort of 1,427 HIV-negative gay men in Australia.
The prevalence of HSV-1 and HSV-2 at baseline was 75% and 23%, respectively. The rate of prevalent infection with HSV-1, as well as the rate of prevalent infection with HSV-2, was much lower in individuals <25 years of age, and each type of infection was associated with a higher number of both male and female sex partners. The median duration of follow-up of the cohort was 2.0 years. Among participants who were susceptible to infection, the incidence rates for HSV-1 and HSV-2 infection were 5.58 and 1.45 cases per 100 person-years, respectively. In multivariate analysis, incident infection with HSV-1 was significantly associated with younger age (P=.027) and reports of frequent insertive oral sex with casual partners (hazard ratio, 3.91 [95% confidence interval, 1.23-12.44]; P=.021). Incident infection with HSV-2 was significantly associated with a variety of anal sex practices with casual partners.
Both HSV-1 and HSV-2 were commonly sexually transmitted, and there were more HSV-1 than HSV-2 seroconversions. Public-health strategies targeted against anogenital herpes increasingly need to take into account the importance of HSV-1 infection.
尽管单纯疱疹病毒1型（HSV-1）相关性肛门生殖器疱疹的报道日益增多，但比较HSV-1和单纯疱疹病毒2型（HSV-2）感染的血清流行病学特征及危险因素的数据却非常有限。
在澳大利亚一个以社区为基础的队列中，对1427名HIV阴性男同性恋者的性行为作为HSV-1和HSV-2感染流行及新发感染的危险因素进行了研究。
基线时HSV-1和HSV-2的患病率分别为75%和23%。25岁以下个体中HSV-1和HSV-2的流行感染率均低得多，且每种感染类型均与更多的男性和女性性伴侣相关。该队列的中位随访时间为2.0年。在易感染参与者中，HSV-1和HSV-2感染的发病率分别为每100人年5.58例和1.45例。多变量分析显示，HSV-1新发感染与较年轻年龄（P=0.027）以及与随意性伴侣频繁进行插入式口交的报告显著相关（风险比，3.91[95%置信区间，1.23 - 12.44]；P=0.021）。HSV-2新发感染与与随意性伴侣的多种肛交行为显著相关。
HSV-1和HSV-2均常见于性传播，且HSV-1血清转换比HSV-2更多。针对肛门生殖器疱疹的公共卫生策略越来越需要考虑HSV-1感染的重要性。
