Moore Cecilia L, Gidding Heather F, Jin Fengyi, Mao Limin, Petoumenos Kathy, Zablotska Iryna B, Poynten I Mary, Prestage Garrett, Law Matthew G, Grulich Andrew E, Amin Janaki
The Kirby Institute, University of New South Wales, Wallace Wurth Building, Sydney, NSW, 2052, Australia.
School of Public Health and Community Medicine, University of New South Wales, Sydney, Australia.
AIDS Behav. 2016 Oct;20(10):2372-2386. doi: 10.1007/s10461-016-1303-3.
We aimed to compare rates of illicit drug-related hospitalisations in HIV-negative (HIV-ve) (n = 1325) and HIV-positive (HIV+ve) (n = 557) gay and bisexual men (GBM) with rates seen in the general male population and to examine the association between self-reported illicit drug use and drug-related hospitalisation. Participants were asked how often they used a range of illicit drugs in the previous 6 months at annual interviews. Drug-related hospital admissions were defined as hospital admissions for mental or behavioural disorders due to illicit drug use (ICD 10: F11-16, F18, F19), drug poisoning (T40-T45, T50) or toxic effect of gases (T53, T59, T65). Drug-related hospitalisations were 4.8 times higher in the HIV-ve cohort [SIR 4.75 (95 % CI 3.30-6.91)] and 3.5 times higher in the HIV+ve cohort [SIR 3.51 (1.92-5.88)] compared with the general population. Periods of weekly drug use [IRR 1.86 (1.01-3.46)], poly-drug use [IRR 2.17 (1.07-4.38)] and cannabis use [low use-IRR 1.95 (1.01-3.77), high use-IRR 2.58 (1.29-5.16)] were associated with drug-related hospitalisation in both cohorts, as was being a consistently high meth/amphetamine user throughout follow-up [IRR 3.24 (1.07-9.83)] and being an inconsistent or consistent injecting drug user throughout follow-up [IRR 3.94 (1.61-9.66), IRR 4.43(1.04-18.76), respectively]. Other risk factors for drug-related hospitalisation indicated the likelihood of comorbid drug and mental health issues in GBM hospitalised for drug use.
我们旨在比较未感染艾滋病毒（HIV阴性，n = 1325）和感染艾滋病毒（HIV阳性，n = 557）的男同性恋者和双性恋男性（GBM）中与非法药物相关的住院率与普通男性人群中的住院率，并研究自我报告的非法药物使用与药物相关住院之间的关联。在年度访谈中，参与者被问及在过去6个月中使用一系列非法药物的频率。与药物相关的住院定义为因非法药物使用导致的精神或行为障碍的住院（国际疾病分类第10版：F11 - 16、F18、F19）、药物中毒（T40 - T45、T50）或气体中毒效应（T53、T59、T65）。与普通人群相比，HIV阴性队列中的药物相关住院率高4.8倍[SIR 4.75（95%CI 3.30 - 6.91）]，HIV阳性队列中的药物相关住院率高3.5倍[SIR 3.51（1.92 - 5.88）]。在两个队列中，每周使用药物的时间段[IRR 1.86（1.01 - 3.46）]、多药使用[IRR 2.17（1.07 - 4.38）]和大麻使用[低使用量 - IRR 1.95（1.01 - 3.77），高使用量 - IRR 2.58（1.29 - 5.16）]都与药物相关住院有关，在整个随访期间持续大量使用甲基苯丙胺[IRR 3.24（1.07 - 9.83）]以及在整个随访期间不定期或持续注射毒品的情况[分别为IRR 3.94（1.61 - 9.66），IRR 4.43（1.04 - 18.76）]也与药物相关住院有关。其他与药物相关住院的风险因素表明，因药物使用住院的GBM中存在药物和心理健康问题合并症的可能性。
