Kentros Clifford
Department of Psychology, Institute of Neuroscience, University of Oregon, Eugene, Oregon, USA.
Hippocampus. 2006;16(9):743-54. doi: 10.1002/hipo.20199.
Neuropsychologists have clearly implicated the hippocampus in the consolidation of memory, particularly episodic memory, the mental replay of past experiences. When recorded from behaving animals, by far the most obvious firing pattern of the primary neurons of the hippocampus is the place field: a cell tends to fire only when the animal's head is in a particular part of its environment. It seems reasonable to suspect that the primary firing correlate of the primary neurons of a structure should underlie the primary function of that structure as revealed by behavioral lesion experiments. However, we are currently still at a loss to explain how the firing of hippocampal neurons contributes to hippocampal function. This review seeks to examine the commonalities between place cells and episodic memory, and posits that an analogy can be made between the stabilization of place fields and the consolidation of memory.
神经心理学家已明确指出海马体在记忆巩固过程中发挥着作用，尤其是情景记忆，即对过去经历的心理重演。当从行为动物身上进行记录时，迄今为止，海马体主要神经元最明显的放电模式是位置野：一个细胞往往仅在动物头部处于其环境的特定部分时才会放电。怀疑一个结构的主要神经元的主要放电关联应是行为损伤实验所揭示的该结构主要功能的基础，这似乎是合理的。然而，我们目前仍然难以解释海马体神经元的放电如何促成海马体功能。这篇综述旨在探讨位置细胞与情景记忆之间的共性，并假定位置野的稳定与记忆巩固之间可以进行类比。
