[Production of interferon-gamma and interleukin-10 by splenic cells of mice infected with Toxoplasma gondii or immunized with antigens of killed parasites].

Splenic lymphocytes from T. gondii infected mice produced high levels of IFN-gamma in vitro. The production of IFN-gamma was increasing until 10-th day of infection, reaching a level 1600-fold higher to that found in control cultures, then it began to decrease. The level of IL-10 released by lymphocytes to the medium was also increasing up to the 10-th day of infection, afterwards its content dropped down to the level 18-fold higher than that at the beginning of experiments. There were no effects of immunization with antigens of killed parasites on the production of IFN-gamma by splenic cells in vitro.