Paul M, Jaworska A, Twardosz-Pawlik H, Szczapa J, Stefaniak J
Klinika Chorób Pasozytniczych i Tropikalnych AM, 60-355 Poznań, ul. Przybyszewskiego 49.
Wiad Parazytol. 2001;47 Suppl 1:107-12.
The effectiveness of neonatal screening for anti-Toxoplasma IgM or IgA and IgM specific antibodies followed by an intensive anti-parasitic therapy for a prevention of clinical and immunological reactivations of congenital infection was studied. Thirty-five congenitally infected infants were included into clinical and serological follow-up. The children were mostly asymptomatic at birth or they expressed some non-specific reversible clinical abnormalities in neonatal period. Clinically overt toxoplasmosis occurred in 10 patients, including one infant with a severe form; 2 children had co-existing CMV infections. During the follow-up period, no clinical relapses were reported. Asymptomatic immunological rebounds of IgG or of IgG and IgA specific antibodies were observed in 16 patients. Anti-parasitic treatment initiated soon after birth seems to be promising in a prevention of early clinical sequelae of congenital T. gondii infection.
研究了新生儿抗弓形虫IgM或IgA及IgM特异性抗体筛查，随后进行强化抗寄生虫治疗以预防先天性感染的临床和免疫反应的有效性。35名先天性感染婴儿纳入临床和血清学随访。这些儿童出生时大多无症状，或在新生儿期表现出一些非特异性可逆性临床异常。10例患者发生临床显性弓形虫病，其中1例为重症；2例儿童合并巨细胞病毒感染。随访期间，未报告临床复发。16例患者观察到IgG或IgG和IgA特异性抗体的无症状免疫反弹。出生后不久开始的抗寄生虫治疗在预防先天性弓形虫感染的早期临床后遗症方面似乎很有前景。
