巴西儿童的结核病治疗中断情况。

Tuberculosis treatment default among Brazilian children.

作者信息

Oliveira V L da Silva, da Cunha A J L A, Alves R

机构信息

Hospital Municipal Jesus, Rio de Janeiro, RJ, Brazil.

出版信息

Int J Tuberc Lung Dis. 2006 Aug;10(8):864-9.

PMID:16898370

Abstract

OBJECTIVES

To study the prevalence and time of tuberculosis (TB) treatment default among children and to compare defaulters with those who completed treatment.

METHODS

Retrospective cohort study at the Hospital Municipal Jesus, Rio de Janeiro, Brazil, among TB patients aged <15 years followed from 1998 to 2002. The group that completed treatment was compared with those that defaulted.

RESULTS

The records of 248 patients were studied. The default rate was 24.2% and was more frequent in the first 2 months of treatment (43.3%) and among those aged <1 year (42.4%). The following variables were associated with default: previous default (relative risk [RR] 1.99, 95%CI 1.12-3.54, P = 0.035), father not living with the child (RR 1.85, 95%CI 1.06-3.21, P = 0.030) and father using illicit drugs (RR 2.93, 95%CI 1.44-5.97, P = 0.002).

CONCLUSIONS

Health professionals responsible for treating children with TB should pay special attention to children aged <1 year, those with a history of previous default, and those whose father is absent or an illicit drug user.

摘要

目的

研究儿童结核病治疗中断的患病率和时间，并将治疗中断者与完成治疗者进行比较。

方法

在巴西里约热内卢市立耶稣医院进行回顾性队列研究，研究对象为1998年至2002年期间随访的15岁以下结核病患者。将完成治疗的组与治疗中断的组进行比较。

结果

对248例患者的记录进行了研究。治疗中断率为24.2%，在治疗的前2个月更为常见（43.3%），在1岁以下儿童中更为常见（42.4%）。以下变量与治疗中断有关：既往治疗中断（相对危险度[RR]1.99，95%可信区间1.12 - 3.54，P = 0.035）、父亲未与孩子同住（RR 1.85，95%可信区间1.06 - 3.21，P = 0.030）以及父亲使用非法药物（RR 2.93，95%可信区间1.44 - 5.97，P = 0.002）。