在存在胶束聚集体的情况下寻找完全未络合的环糊精。
In search of fully uncomplexed cyclodextrin in the presence of micellar aggregates.
作者信息
Cabaleiro-Lago C, García-Río L, Hervés P, Mejuto J C, Pérez-Juste J
机构信息
Departamento de Química Física, Facultad de Química, Universidad de Vigo, 36310 Vigo, Spain.
出版信息
J Phys Chem B. 2006 Aug 17;110(32):15831-8. doi: 10.1021/jp0626871.
The chemical behavior of beta-cyclodextrin/nonionic surfactant mixed systems has been investigated using the basic hydrolysis of N-methyl-N-nitroso-p-toluenesulfonamide as a chemical probe. The experimental results prove that at the cmc, there are significant quantities of uncomplexed beta-CD in equilibrium with the micellar aggregates. In contrast to the expected situation, the percentage of uncomplexed beta-CD in equilibrium with the micellar system increases on increasing the hydrophobicity of the surfactant molecule. This behavior is due to the existence of two simultaneous processes: complexation of surfactant monomers by cyclodextrin and the process of self-assembly to form micellar aggregates. The autoaggregation of surfactant monomers is expected to be more important than the complexation process in this mixed system. Varying the hydrophobicity of the surfactant monomer enabled us to determine that the percentages of uncomplexed cyclodextrin in equilibrium with the micellar system were in the range of 5-95%.
以N-甲基-N-亚硝基对甲苯磺酰胺的碱性水解作为化学探针，研究了β-环糊精/非离子表面活性剂混合体系的化学行为。实验结果表明，在临界胶束浓度（cmc）时，有大量未络合的β-环糊精与胶束聚集体处于平衡状态。与预期情况相反，随着表面活性剂分子疏水性的增加，与胶束体系处于平衡状态的未络合β-环糊精的百分比增加。这种行为是由于两个同时发生的过程：环糊精对表面活性剂单体的络合以及自组装形成胶束聚集体的过程。在该混合体系中，表面活性剂单体的自聚集预计比络合过程更重要。改变表面活性剂单体的疏水性使我们能够确定，与胶束体系处于平衡状态的未络合环糊精的百分比在5%至95%的范围内。
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