一种多功能且实用的手性位移试剂，在大环腔内具有氢键供体/受体位点。

Versatile and practical chiral shift reagent with hydrogen-bond donor/acceptor sites in a macrocyclic cavity.

作者信息

Ema Tadashi, Tanida Daisuke, Sakai Takashi

机构信息

Division of Chemistry and Biochemistry, Graduate School of Natural Science and Technology, Okayama University, Tsushima, Okayama 700-8530, Japan.

出版信息

Org Lett. 2006 Aug 17;8(17):3773-5. doi: 10.1021/ol0613665.

DOI:10.1021/ol0613665

PMID:16898814

Abstract

[structure: see text] Bifunctional macrocycle 1 with C2 symmetry was newly synthesized. NMR studies demonstrated that receptor 1 functions as a chiral shift reagent (solvating agent) that is highly effective for a wide range of chiral compounds having a carboxylic acid, oxazolidinone, lactone, alcohol, sulfoxide, sulfoximine, isocyanate, or epoxide functionality. Binding constants were determined to investigate the binding behavior of 1.

摘要

[结构：见文本] 新合成了具有C2对称性的双功能大环化合物1。核磁共振研究表明，受体1作为一种手性位移试剂（溶剂化剂），对多种具有羧酸、恶唑烷酮、内酯、醇、亚砜、磺胺肟、异氰酸酯或环氧化物官能团的手性化合物非常有效。测定了结合常数以研究1的结合行为。