抗甲状腺药物治疗甲状腺毒症后碘有机化缺陷。

Iodine organification defect following treatment of thyrotoxicosis with antithyroid drugs.

作者信息

Horton P W, Millar W T, McLarty D G, Alexander W D

出版信息

Clin Endocrinol (Oxf). 1975 Jul;4(4):357-62. doi: 10.1111/j.1365-2265.1975.tb01544.x.

DOI:10.1111/j.1365-2265.1975.tb01544.x

Abstract

Two patients remained clinically euthyroid following treatment for thyrotoxicosis with antithyroid drugs in spite of persistently elevated thyroid radioiodine uptakes not suppressable by exogenous triiodothyronine. Perchlorate discharge tests showed a defect in the intrathyroidal organification of iodine. Circulating levels of thyroxine were normal. From our study of 105 patients treated for thyrotoxicosis with antithyroid drugs, apparent remission of thyrotoxicosis by this mechanism might occur in up to 2 percent of patients.

摘要

两名甲状腺毒症患者在接受抗甲状腺药物治疗后，临床症状上仍处于甲状腺功能正常状态，尽管甲状腺放射性碘摄取持续升高且不能被外源性三碘甲状腺原氨酸所抑制。高氯酸盐释放试验显示甲状腺内碘有机化存在缺陷。甲状腺素的循环水平正常。在我们对105例接受抗甲状腺药物治疗的甲状腺毒症患者的研究中，高达2%的患者可能通过这种机制出现甲状腺毒症的明显缓解。