Wada Tetsuro, Uemaetomari Isao, Murashita Hidekazu, Tobita Tadamichi, Tsuji Shigeki, Tabuchi Keiji, Okubo Hideki, Hara Akira
Department of Otolaryngology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennnodai, Tsukuba, Ibaraki, Japan.
Auris Nasus Larynx. 2006 Dec;33(4):455-60. doi: 10.1016/j.anl.2006.05.007. Epub 2006 Aug 8.
The pathogenesis of eosinophilic otitis media is not yet fully understood. The purpose of this paper is to describe the clinical course of our two patients with eosinophilic otitis media and to discuss the pathogenesis and treatment of this intractable condition.
Two cases of eosinophilic otitis media were treated with ramatroban.
The middle ear effusion has been well controlled in both patients for more than 1 year with minimal corticosteroid therapy.
Our experience suggests that the pathogenesis of eosinophilic otitis media is related to the pharmaceutical effects of ramatroban, i.e., inhibition of the thromboxane A2 receptor (TP) and the chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2).
嗜酸性粒细胞性中耳炎的发病机制尚未完全明确。本文旨在描述我们收治的两名嗜酸性粒细胞性中耳炎患者的临床病程，并探讨这种难治性疾病的发病机制及治疗方法。
两例嗜酸性粒细胞性中耳炎患者接受了雷马曲班治疗。
在最低限度的皮质类固醇治疗下，两名患者的中耳积液均得到了良好控制，持续时间超过1年。
我们的经验表明，嗜酸性粒细胞性中耳炎的发病机制与雷马曲班的药理作用有关，即抑制血栓素A2受体（TP）和Th2细胞上表达的趋化因子受体同源分子（CRTH2）。
