Baumeister Ralf, Schaffitzel Elke, Hertweck Maren
Bio 3, Bioinformatics and Molecular Genetics, University of Freiburg, Germany.
J Endocrinol. 2006 Aug;190(2):191-202. doi: 10.1677/joe.1.06856.
Modulation of insulin/IGF signaling in the nematode Caenorhabditis elegans is the central determinant of the endocrine control of stress response, diapause, and aging. Mutations in many genes that interfere with, or are controlled by, insulin signaling have been identified in the last decade by genetic analyses in the worm. Most of these genes have orthologs in vertebrate genomes, and their functional characterization has provided multiple hints about conserved mechanisms for the genetic influence on aging. The emerging picture is that insulin-like molecules, through the activity of the DAF-2/insulin/ IGF-I-like receptor, and the DAF-16/FKHRL1/FOXO transcription factor, control the ability of the organism to deal with oxidative stress, and interfere with metabolic programs that help to determine lifespan.
线虫秀丽隐杆线虫中胰岛素/胰岛素样生长因子信号的调节是应激反应、滞育和衰老的内分泌控制的核心决定因素。在过去十年中，通过对线虫的遗传分析，已经鉴定出许多干扰胰岛素信号或受胰岛素信号控制的基因中的突变。这些基因中的大多数在脊椎动物基因组中有直系同源物，它们的功能特征为遗传对衰老影响的保守机制提供了多个线索。新出现的情况是，胰岛素样分子通过DAF-2/胰岛素/胰岛素样生长因子-I样受体和DAF-16/FKHRL1/FOXO转录因子的活性，控制生物体应对氧化应激的能力，并干扰有助于确定寿命的代谢程序。
