Tsukagoshi S
Cancer Chemotherapy Center, Japanese Foundation for Cancer Research.
Gan To Kagaku Ryoho. 1990 Mar;17(3 Pt 1):342-51.
Currently many antitumor candidate compounds are under clinical trials in Japan. These compounds include synthetic compounds and natural products and their chemical modifiers. Concerning synthetics, fluoropyrimidines and other antimetabolites, cisplatin analogues and other compounds are in phase I or II trials. As for the natural products, antitumor antibiotics including anthracyclines, bleomycin analogue and others and chemically modified plant products are major candidate compounds under phase I or II trials. We are expecting to develop clinically useful drugs among these compounds which have been in clinical trials currently in Japan.
目前，许多抗肿瘤候选化合物正在日本进行临床试验。这些化合物包括合成化合物、天然产物及其化学修饰物。在合成化合物方面，氟嘧啶和其他抗代谢物、顺铂类似物及其他化合物正处于I期或II期试验。至于天然产物，包括蒽环类抗生素、博来霉素类似物等在内的抗肿瘤抗生素以及化学修饰的植物产物是处于I期或II期试验的主要候选化合物。我们期望能从目前正在日本进行临床试验的这些化合物中开发出临床有用的药物。
