[伴有梭形和/或巨细胞的肺癌的病理学研究]

[Pathological study of pulmonary carcinomas with spindle and/or giant cells].

作者信息

Huo Zhen, Liu Hong-Rui

机构信息

Department of Pathology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.

出版信息

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2006 Jun;28(3):391-4.

PMID:16900641

Abstract

OBJECTIVE

To study the pathologic features of pulmonary carcinomas with spindle and/or giant cells.

METHODS

Twenty cases of pulmonary carcinomas with spindle and/or giant cells were studied by using lightmicroscopy and immunohistochemical staining.

RESULTS

Of 20 cases, 15 cases were pleomorphic carcinoma (10 cases with adenocarcinoma, 3 cases with large cell carcinoma, 1 case with squamous cell carcinoma and 1 case with giant cell carcinoma) , 4 cases were spindle cell carcinoma, and 1 case was giant cell carcinoma. Immunohistochemical results showed AE1/AE3 was positive in the spindle and/or giant cell component of 19 cases, Vimentin was positive in the spindle and/or giant cell component of 20 cases, P53 was positive in 10 cases and thyoid transcription factor-1 (TTF-1) was negtive in all cases.

CONCLUSIONS

Pulmonary carcinomas with spindle and/or giant cells is definded as a group of poorly differentiated non-small cell carcinoma that contains a component of spindle and/or giant cells. The diagnosis is based on histopathology and immunohistochemical staining of AE1/AE3 and Vimentin.

摘要

目的

研究具有梭形和/或巨细胞的肺癌的病理特征。

方法

采用光学显微镜和免疫组织化学染色对20例具有梭形和/或巨细胞的肺癌进行研究。

结果

20例中，15例为多形性癌（腺癌10例、大细胞癌3例、鳞状细胞癌1例、巨细胞癌1例），4例为梭形细胞癌，1例为巨细胞癌。免疫组织化学结果显示，19例的梭形和/或巨细胞成分中AE1/AE3呈阳性，20例的梭形和/或巨细胞成分中波形蛋白呈阳性，10例P53呈阳性，所有病例甲状腺转录因子-1（TTF-1）均为阴性。