Faine Luciane A, Rodrigues Hosana G, Galhardi Cristiano M, Ebaid Geovana M X, Diniz Yeda S, Padovani Carlos R, Novelli Ethel L B
Department of Chemistry and Biochemistry, Institute of Biological Sciences, University Estadual Paulista, UNESP, 18618-000 Botucatu, São Paulo, Brazil.
Can J Physiol Pharmacol. 2006 Feb;84(2):239-45. doi: 10.1139/y05-124.
Recent lines of evidence suggest that the beneficial effects of olive oil are not only related to its high content of oleic acid, but also to the antioxidant potential of its polyphenols. The aim of this work was determine the effects of olive oil and its components, oleic acid and the polyphenol dihydroxyphenylethanol (DPE), on serum lipids, oxidative stress, and energy metabolism on cardiac tissue. Twenty four male Wistar rats, 200 g, were divided into the following 4 groups (n = 6): control (C), OO group that received extra-virgin olive oil (7.5 mL/kg), OA group was treated with oleic acid (3.45 mL/kg), and the DPE group that received the polyphenol DPE (7.5 mg/kg). These components were administered by gavage over 30 days, twice a week. All animals were provided with food and water ad libitum. The results show that olive oil was more effective than its isolated components in improving lipid profile, elevating high-density lipoprotein, and diminishing low-density lipoprotein cholesterol concentrations. Olive oil induced decreased antioxidant Mn-superoxide dismutase activity and diminished protein carbonyl concentration, indicating that olive oil may exert direct antioxidant effect on myocardium. DPE, considered as potential antioxidant, induced elevated aerobic metabolism, triacylglycerols, and lipid hydroperoxides concentrations in cardiac muscle, indicating that long-term intake of this polyphenol may induce its undesirable pro-oxidant activity on myocardium.
最近的一系列证据表明，橄榄油的有益作用不仅与其油酸含量高有关，还与其多酚的抗氧化潜力有关。这项工作的目的是确定橄榄油及其成分油酸和多酚二羟基苯乙醇（DPE）对心脏组织的血脂、氧化应激和能量代谢的影响。将24只体重200克的雄性Wistar大鼠分为以下4组（n = 6）：对照组（C）、接受特级初榨橄榄油的OO组（7.5毫升/千克）、用油酸治疗的OA组（3.45毫升/千克）以及接受多酚DPE的DPE组（7.5毫克/千克）。这些成分通过灌胃给药30天，每周两次。所有动物均可自由获取食物和水。结果表明，在改善血脂谱、提高高密度脂蛋白以及降低低密度脂蛋白胆固醇浓度方面，橄榄油比其分离成分更有效。橄榄油可降低抗氧化锰超氧化物歧化酶活性并减少蛋白质羰基浓度，这表明橄榄油可能对心肌发挥直接抗氧化作用。被视为潜在抗氧化剂的DPE可导致心肌有氧代谢、三酰甘油和脂质氢过氧化物浓度升高，这表明长期摄入这种多酚可能会对心肌产生不良的促氧化活性。
