de Leeuw P W
Academisch Ziekenhuis Maastricht, afd. Interne Geneeskunde, Postbus 5800, 6202 AZ Maastricht.
Ned Tijdschr Geneeskd. 2006 Jul 22;150(29):1605-7.
Recently, an important study was published concerning the possible teratogenic effects of angiotensin converting enzyme (ACE) inhibitors. Non-diabetic women who had used an ACE inhibitor during the first trimester of pregnancy had a significantly greater chance of giving birth to an infant with congenital malformations than women who had used no or other antihypertensive agents. The excess risk remained even after adjusting for several potential confounders. The results indicate that ACE inhibitors should not be prescribed to women who are likely to become pregnant during the course of treatment.
最近，发表了一项关于血管紧张素转换酶（ACE）抑制剂可能致畸作用的重要研究。在妊娠头三个月使用过ACE抑制剂的非糖尿病女性，比起未使用或使用其他抗高血压药物的女性，生下先天性畸形婴儿的几率要高得多。即使在对几个潜在混杂因素进行调整之后，这种额外风险依然存在。结果表明，对于在治疗过程中可能怀孕的女性，不应开具ACE抑制剂的处方。
