Department of Psychiatry, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Erie County Medical Center, 462 Grider Street, Buffalo, NY 14215, USA.
Curr Treat Options Neurol. 2006 Sep;8(5):389-400. doi: 10.1007/s11940-006-0028-4.
Neuropathy is a relatively common source of acute and chronic pain. Emerging evidence suggests several pathophysiological mechanisms underlying the neuropathic pain associated with various disorders. Antidepressants and anticonvulsants have largely been the mainstay of treatment. Pharmacologic treatment of neuropathy frequently requires use of multiple medications. Ideally, the selection of which medications to use should be based on targeting the multiple pathophysiologic mechanisms contributing to neuropathic pain transmission. Psychological variables may play a role in predisposing patients to chronic neuropathy after acute illness. In addition, comorbid conditions, especially depression, can complicate the presentation, clinical course, and response to treatment of patients with chronic pain. Treatment of depression may be essential to fully enlist the chronic neuropathic pain patient in comprehensive pain management and rehabilitative approaches.
神经病学是一种相对常见的急性和慢性疼痛源。新出现的证据表明，多种与疾病相关的神经病学疼痛存在几种病理生理学机制。抗抑郁药和抗惊厥药在很大程度上一直是治疗的主要方法。神经病学的药物治疗通常需要使用多种药物。理想情况下，选择使用哪种药物应该基于针对导致神经病学疼痛传递的多种病理生理学机制。心理变量可能在急性疾病后使患者易患慢性神经病学方面发挥作用。此外，合并症，特别是抑郁症，会使慢性疼痛患者的表现、临床病程和对治疗的反应复杂化。治疗抑郁症对于充分参与慢性神经病理性疼痛患者的全面疼痛管理和康复方法可能至关重要。
