Mante S, Minneman K P
Department of Pharmacology, Emory University Medical School, Atlanta, GA 30322.
Eur J Pharmacol. 1990 Jan 10;175(2):203-5. doi: 10.1016/0014-2999(90)90231-t.
Caffeine potently inhibited forskolin-stimulated cyclic AMP accumulation in slices of rat cerebral cortex. The IC50 for this inhibition was 21 +/- 2.9 microM, and 200 microM caffeine almost completely blocked the forskolin response. Theophylline which is a behavioural stimulant mimicked the effect of caffeine. However, there was only a slight inhibition of the forskolin response by theobromine and IBMX (3-isobutyl-1-methylxanthine), both of which lack behavioral stimulant effects.
咖啡因能有效抑制福斯高林刺激的大鼠大脑皮层切片中环磷酸腺苷（cAMP）的积累。这种抑制作用的半数抑制浓度（IC50）为21±2.9微摩尔，200微摩尔的咖啡因几乎完全阻断了福斯高林反应。作为行为兴奋剂的茶碱模拟了咖啡因的作用。然而，可可碱和3 -异丁基-1 -甲基黄嘌呤（IBMX）对福斯高林反应仅有轻微抑制，这两者均无行为兴奋作用。
