Aydin Omer Faruk, Senbil Nesrin, Gürer Y K Yavuz
Department of Pediatric Neurology, Dr. Sami Ulus Children's Hospital, Ankara, Turkey.
J Child Neurol. 2006 Mar;21(3):256-60. doi: 10.2310/7010.2006.00056.
Subacute sclerosing panencephalitis is a neurodegenerative disease with a poor prognosis. We report a case of a 5 1/2-year-old boy who had emotional lability, cognitive difficulties, and myoclonia after a mild closed head injury. The magnetic resonance image of the brain and computed tomographic scan of the head were normal. His electroencephalogram (EEG) showed continuous nonconvulsive status epilepticus activity, which could not be suppressed with intravenous diazepam. After treatment with phenytoin for 2 days, an EEG showed periodic high-amplitude sharp-and-slow-wave complexes, which were also not suppressed with intravenous diazepam. Since the patient had measles at 5 months of age, subacute sclerosing panencephalitis was considered, and the diagnosis was confirmed by the presence of measles antibodies in cerebrospinal fluid.
亚急性硬化性全脑炎是一种预后不良的神经退行性疾病。我们报告一例5岁半男孩，在轻度闭合性头部损伤后出现情绪不稳定、认知困难和肌阵挛。脑部磁共振成像和头部计算机断层扫描均正常。他的脑电图（EEG）显示持续的非惊厥性癫痫持续状态活动，静脉注射地西泮无法抑制。用苯妥英治疗2天后，脑电图显示周期性高幅尖慢波复合波，静脉注射地西泮也无法抑制。由于该患者5个月大时患过麻疹，故考虑为亚急性硬化性全脑炎，脑脊液中麻疹抗体的存在证实了诊断。
