Yilmaz Kutluhan, Sahin Derya Aydin
Department of Pediatrics, Gaziantep University, Faculty of Medicine, Gaziantep, Turkey.
J Child Neurol. 2010 Aug;25(8):994-9. doi: 10.1177/0883073809357239. Epub 2010 Feb 5.
Although diagnostic contribution of intravenous diazepam administration during electroencephalography (EEG) recording in subacute sclerosing panencephalitis has been known, no another drug with less potential side effects has been studied in this procedure. In this study, diazepam is compared with midazolam in 25 subacute sclerosing panencephalitis-diagnosed children and 10 children with subacute sclerosing panencephalitis-suggesting symptoms, normal EEG findings and no certain diagnosis. Neither midazolam nor diazepam affected typical periodic slow-wave complexes. However, in the patients with atypical EEG abnormalities, midazolam, like diazepam, attenuated sharp or sharp-and-slow waves, and therefore made the identification of periodic slow-wave paroxysms easier. In the patients with normal EEGs, both midazolam and diazepam revealed typical periodic complexes on EEG recording in the same 3 patients. Cerebrospinal fluid examination verified the diagnosis of subacute sclerosing panencephalitis. The findings suggest that midazolam or diazepam administration increases the contribution of EEG recording in atypical cases with subacute sclerosing panencephalitis.
虽然在亚急性硬化性全脑炎的脑电图（EEG）记录过程中静脉注射地西泮的诊断作用已为人所知，但在此过程中尚未对其他潜在副作用较小的药物进行研究。在本研究中，对25例诊断为亚急性硬化性全脑炎的儿童和10例有亚急性硬化性全脑炎疑似症状、EEG结果正常且未明确诊断的儿童，将地西泮与咪达唑仑进行了比较。咪达唑仑和地西泮均未影响典型的周期性慢波复合波。然而，在EEG异常不典型的患者中，咪达唑仑与地西泮一样，减弱了锐波或锐慢波，因此使周期性慢波阵发的识别更容易。在EEG正常的患者中，咪达唑仑和地西泮在相同的3例患者的EEG记录中均显示出典型的周期性复合波。脑脊液检查证实了亚急性硬化性全脑炎的诊断。这些发现表明，在亚急性硬化性全脑炎的非典型病例中，给予咪达唑仑或地西泮可增加EEG记录的作用。
