Effect of 1-deamino 8-D-arginine vasopressin spray on nasal cytology and mucociliary clearance in patients with nocturnal enuresis.
作者信息
Akoğlu Ertap, Görür Sadik, Atik Esin, Okuyucu Semsettin, Sangün Ozlem
机构信息
Mustafa Kemal University, Faculty of Medicine, Department of Oto-Rhino-Laryngology, Head and Neck Surgery, 31100 Antakya, Hatay, Turkey.
出版信息
Int J Pediatr Otorhinolaryngol. 2006 Nov;70(11):1919-22. doi: 10.1016/j.ijporl.2006.06.019. Epub 2006 Aug 9.
OBJECTIVE
To determine any possible adverse effect of 1-deamino 8-D-arginine vasopressin (DDAVP) spray on nasal cytology and mucociliary clearance in patients with nocturnal enuresis.
METHODS
Twenty-two children aged 6-16 enrolled in the study. Epithelial surface cells samples were taken from the nasal mucosa and mucociliary clearance time was calculated before and 1 and 6 months after administration of DDAVP spray.
RESULTS
No qualitative changes in the epithelial surface cells and mucociliary clearance time were observed at 1 and 6 months after therapy.
CONCLUSION
Based on the findings of the present study, DDAVP spray can be used for 6 months in children without apparent risk of damage to the epithelial surface cells and mucociliary clearance time.
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