Shults Clifford W, Barrett Jennifer M, Fontaine Deborah
Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093-0662, USA.
Neurosci Lett. 2006 Sep 25;405(3):223-5. doi: 10.1016/j.neulet.2006.07.006. Epub 2006 Aug 9.
Parkinson's disease (PD) and multiple system atrophy (MSA) are characterized pathologically by inclusions in the brain containing alpha-synuclein, which is phosphorylated at serine 129. alpha-Synuclein is present not only in the brain but also in platelets; platelets have previously been used to study mitochondrial function in PD. We undertook to determine whether alpha-synuclein extracted from platelets of patients with PD and MSA is phosphorylated at serine 129 and could be used as a peripheral marker of these disorders. Immunoblots indicated that platelet alpha-synuclein is not phosphorylated at serine 129 in PD and MSA.
帕金森病（PD）和多系统萎缩（MSA）在病理上的特征是大脑中含有在丝氨酸129处磷酸化的α-突触核蛋白的包涵体。α-突触核蛋白不仅存在于大脑中，也存在于血小板中；血小板此前已被用于研究PD中的线粒体功能。我们旨在确定从PD和MSA患者血小板中提取的α-突触核蛋白是否在丝氨酸129处磷酸化，以及是否可作为这些疾病的外周标志物。免疫印迹表明，PD和MSA患者血小板中的α-突触核蛋白在丝氨酸129处未磷酸化。
