新型5'-降碳环膦酸核苷的合成与抗病毒评价
Synthesis and antiviral evaluation of novel 5'-norcarboacyclic phosphonic acid nucleosides.
作者信息
Kim Aihong, Hong Joon Hee
机构信息
College of Pharmacy, Chosun University, Kwangju, Republic of Korea.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2006;25(8):941-50. doi: 10.1080/15257770600793927.
PMID:16901824
Abstract
This article describes a very simple route for synthesizing a novel 5'-norcarboacyclic nucleotides. The condensation of the mesylates 17 and 18 with the natural nucleosidic bases (A,U,T,C) under standard nucleophilic substitution (K2CO3, 18-Crown-6, DMF) and deprotection afforded the target nucleotide analogues 27-34. In addition, these compounds were evaluated for their antiviral properties against various viruses.
摘要
本文描述了一种合成新型5'-降碳环核苷酸的非常简单的路线。甲磺酸酯17和18与天然核苷碱基（A、U、T、C）在标准亲核取代反应（碳酸钾、18-冠醚-6、N,N-二甲基甲酰胺）条件下缩合并脱保护，得到目标核苷酸类似物27 - 34。此外，还评估了这些化合物对各种病毒的抗病毒特性。
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