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2'-脱氧嘧啶核苷快速合成 2',3'-二脱氧-3'β-氟嘧啶核苷。

Rapid synthesis of 2',3'-dideoxy-3'β-fluoro-pyrimidine nucleosides from 2'-deoxypyrimidine nucleosides.

机构信息

Institut des Biomolécules Max Mousseron, UMR CNRS-UM, Université Montpellier, France.

出版信息

Bioorg Chem. 2010 Dec;38(6):271-4. doi: 10.1016/j.bioorg.2010.08.003. Epub 2010 Sep 7.

DOI:10.1016/j.bioorg.2010.08.003
PMID:20869741
Abstract

A rapid synthesis of 2',3'-dideoxy-3'-fluoro-β-D-threo-nucleosides bearing the pyrimidine canonical bases of nucleic acids has been developed in order to discover new nucleoside derivatives as potential antiviral drugs. However, when evaluated for their antiviral activity in cell culture experiments, none of these compounds showed any significant antiviral activity.

摘要

为了发现新的核苷衍生物作为潜在的抗病毒药物，我们开发了一种快速合成带有核酸嘧啶规范碱基的 2',3'-二脱氧-3'-氟-β-D-赤式核苷的方法。然而，当在细胞培养实验中评估它们的抗病毒活性时，这些化合物都没有显示出任何显著的抗病毒活性。

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