Fahrenkrog Birthe
ME Müller Institute for Structural Biology, Biozentrum, University of Basel, Switzerland.
Can J Physiol Pharmacol. 2006 Mar-Apr;84(3-4):279-86. doi: 10.1139/y05-100.
The nuclear pore complex (NPC) is the sole gateway between the nucleus and the cytoplasm of interphase eukaryotic cells, and it mediates all trafficking between these 2 cellular compartments. As such, the NPC and nuclear transport play central roles in translocating death signals from the cell membrane to the nucleus where they initiate biochemical and morphological changes occurring during apoptosis. Recent findings suggest that the correlation between the NPC, nuclear transport, and apoptosis goes beyond the simple fact that NPCs mediate nuclear transport of key players involved in the cell death program. In this context, the accessibility of key regulators of apoptosis appears to be highly modulated by nuclear transport (e.g., impaired nuclear import might be an apoptotic trigger). In this review, recent findings concerning the unexpected tight link between NPCs, nuclear transport, and apoptosis will be presented and critically discussed.
核孔复合体（NPC）是间期真核细胞细胞核与细胞质之间的唯一通道，它介导这两个细胞区室之间的所有物质运输。因此，NPC和核运输在将死亡信号从细胞膜转运至细胞核的过程中起着核心作用，在细胞核中这些信号引发细胞凋亡过程中发生的生化和形态学变化。最近的研究结果表明，NPC、核运输与细胞凋亡之间的关联不仅仅在于NPC介导参与细胞死亡程序的关键分子的核运输这一简单事实。在这种情况下，细胞凋亡关键调节因子的可及性似乎受到核运输的高度调控（例如，核输入受损可能是细胞凋亡的触发因素）。在这篇综述中，将介绍并批判性地讨论有关NPC、核运输与细胞凋亡之间意外紧密联系的最新研究结果。
