[Extra-islet cells of pancreas during the diabetes of alloxan and after the action of plaferon].

Using the methods of light and electron microscopy, pancreas was studied in the experimental model of alloxan diabetes (AD) at various times of the experiment (1 and 6 month) at different degrees of AD and after the action of plaferon. The special emphasis was made on display of compensatory changes that is opportunity of occurrence in extra-islet cells special granules, characteristic for insulin producing B-cells. During the development of pathological processes, there were detected intermediate cells including exocrine and endocrine granules. Some of these cells were located near the acini and some of them were in close contact with duct cells. It is suggested that these intermediate extra-islet cells are especial cells with high functional activity, they are transitional form during the processes of transformation into endocrine ones, possibly these cells are precursors of islet cells. It is possible, that plaferon acts on processes of transformation and differentiation of extra-islet cells and takes part in neogenesis of B-cells.