Kavitha J V, Rosario Joseph F, Chandran J, Anbu P
LN College of Pharmacy, Bhopal.
Indian J Physiol Pharmacol. 2007 Jan-Mar;51(1):29-39.
The hypoglycemic effect of the aqueous extract of the leaves and roots of Boswellia glabra was examined using alloxan-induced diabetic rats. A single oral administration of Boswellia glabra leaf and root extract decreased the blood glucose level. The continued use of leaf and root extract for 28 days produced significant hypoglycemic effects; also there was a decrease in serum glucose, cholesterol, triglyceride, urea and creatinine levels and enzyme activities (alkaline phosphatase and glucose-6-phosphatase). Ultra structural studies of beta cell of alloxan-induced diabetic rats treated with root extract showed numerous granulated sacs in comparison to rats treated with leaf extract. Thus, rats treated with root extract showed less degranulated sacs and more number of filled secretory granules in comparison to diabetic rats. Thus the use of aqueous extract of Boswellia glabra increased the synthesis of secretory granules in the beta-cell.
使用四氧嘧啶诱导的糖尿病大鼠研究了乳香树叶和根水提取物的降血糖作用。单次口服乳香树叶和根提取物可降低血糖水平。连续28天使用叶和根提取物产生了显著的降血糖作用；血清葡萄糖、胆固醇、甘油三酯、尿素和肌酐水平以及酶活性（碱性磷酸酶和葡萄糖-6-磷酸酶）也有所降低。用根提取物处理的四氧嘧啶诱导的糖尿病大鼠β细胞的超微结构研究显示，与用叶提取物处理的大鼠相比，有大量颗粒状囊泡。因此，与糖尿病大鼠相比，用根提取物处理的大鼠显示出较少的脱颗粒囊泡和更多数量的充满分泌颗粒。因此，使用乳香树水提取物增加了β细胞中分泌颗粒的合成。
