Flint Michael N, Griffin Anthony M, Bell Robert S, Ferguson Peter C, Wunder Jay S
University Musculoskeletal Oncology Unit, Mount Sinai Hospital, 476E-600 University Avenue, Toronto, Ontario M5G 1X5, Canada.
Clin Orthop Relat Res. 2006 Sep;450:52-9. doi: 10.1097/01.blo.0000229300.67394.77.
Aseptic loosening is a frequent cause of failure of cemented proximal tibia tumor endoprostheses. Uncemented prostheses may lessen this risk. We identified complications including aseptic loosening that affected prosthetic survival, limb survival and functional outcome for 44 consecutive patients after sarcoma resection from the proximal tibia and uncemented endoprosthetic reconstruction. At a mean final followup of 60 months (range, 9-152 months), there were no cases of aseptic loosening. Twelve (27%) patients suffered 14 complications leading to prosthetic failure due to infection (n = 7), stem fracture (n = 2), rotational instability (n = 1), vascular compromise (n = 2) and local tumor relapse (n = 2). However, limb salvage was successful in 37 of 44 (84%) patients. Functional assessment for 35 patients revealed a mean Toronto Extremity Salvage Score of 77/100 (range, 33-98) and Musculoskeletal Tumor Society 1987 and 1993 scores of 25/35 (range, 13-31) and 75/100 (range, 33-97), respectively. Mean knee joint flexion was 91 degrees (range, 0-110 degrees ) and knee extension lag was 6 degrees (range, 0-30 degrees ). Three patients with knee extensor complications had inferior functional outcomes. Aseptic loosening is uncommon with uncemented proximal tibia reconstruction, but decreasing other complications at this location remains challenging.
Therapeutic study, level IV-1 (case series).
无菌性松动是骨水泥型近端胫骨肿瘤假体失败的常见原因。非骨水泥型假体可能会降低这种风险。我们确定了44例连续的胫骨近端肉瘤切除及非骨水泥型假体重建术后患者中影响假体存活、肢体存活和功能结果的并发症,包括无菌性松动。平均最终随访60个月(范围9 - 152个月),无无菌性松动病例。12例(27%)患者出现14种并发症,导致假体失败,原因包括感染(n = 7)、柄部骨折(n = 2)、旋转不稳定(n = 1)、血管受压(n = 2)和局部肿瘤复发(n = 2)。然而,44例患者中有37例(84%)保肢成功。对35例患者的功能评估显示,多伦多肢体挽救评分平均为77/100(范围33 - 98),肌肉骨骼肿瘤学会1987年和1993年评分分别为25/35(范围13 - 31)和75/100(范围33 - 97)。膝关节平均屈曲度为91度(范围0 - 110度),膝关节伸直滞后为6度(范围0 - 30度)。3例有膝关节伸肌并发症的患者功能结果较差。非骨水泥型近端胫骨重建时无菌性松动不常见,但减少该部位的其他并发症仍然具有挑战性。
治疗性研究,IV - 1级(病例系列)。