Rapaccini G L, Pompili M, Caturelli E, Anti M, Aliotta A, Cedrone A, Amadei E, Grattagliano A, Squillante M M, Rabitti C
Istituto di Clinica Medica, Università Cattolica del Sacro Cuore, Roma, Italy.
Dig Dis Sci. 1990 Apr;35(4):422-7. doi: 10.1007/BF01536913.
In the period 1985-1988, 62 focal liver lesions in 58 cirrhotic patients were studied by ultrasonography; 12 of these focal lesions were documented to be regenerating lesions by echo-guided fine-needle biopsy. During an average follow-up period of 10.2 months (range 3-22 months), hepatocellular carcinoma was subsequently found in 10 of the cases of regenerating nodules, whereas the initial diagnosis of regenerating nodule was confirmed in the remaining two cases. Based upon this finding, it is suggested that every focal mass visualized by ultrasonography in a cirrhotic liver should either be considered to be a neoplastic lesion or at least a preneoplastic lesion if the possibility of either a metastatic or benign lesion (eg, hemangiomas, focal fatty liver change areas) can be excluded. Therefore either fine-needle aspiration or biopsy of all ultrasonographically revealed mass lesions within a cirrhotic liver is advised, such that early appropriate treatment for hepatocellular carcinoma can be instituted.
在1985年至1988年期间，对58例肝硬化患者的62个肝脏局灶性病变进行了超声检查；其中12个局灶性病变经超声引导下细针穿刺活检证实为再生性病变。在平均10.2个月（范围3至22个月）的随访期内，随后在10例再生结节病例中发现了肝细胞癌，而其余2例则证实了最初的再生结节诊断。基于这一发现，建议对于肝硬化肝脏中超声检查发现的每个局灶性肿块，如果可以排除转移性或良性病变（如血管瘤、局灶性脂肪肝改变区域）的可能性，则应将其视为肿瘤性病变或至少是癌前病变。因此，建议对肝硬化肝脏中所有超声检查发现的肿块性病变进行细针抽吸或活检，以便能够尽早对肝细胞癌进行适当治疗。
