Béné Marie Christine
Immunology Laboratory, Faculty of Medicine & CHU, Nancy, France.
Cytometry B Clin Cytom. 2006 Jul 15;70(4):204-8. doi: 10.1002/cyto.b.20124.
Zap-70, a crucial molecule for the selective activation of T cells, through its interaction with the zeta chain of the TCR/CD3 complex, is a tyrosine kinase. This well studied molecule has gained a renewed interest upon the demonstration of its transduction and expression in B cells from patients with chronic lymphocytic leukemia. Here the major characteristics of this cytosolic protein are reviewed, as well as its expression in various cell types and some indications about its detection.
Zap-70是一种酪氨酸激酶，通过与TCR/CD3复合物的ζ链相互作用，在T细胞的选择性激活中起着关键作用。在慢性淋巴细胞白血病患者的B细胞中证实其转导和表达后，这个已被充分研究的分子重新引起了人们的兴趣。本文综述了这种胞质蛋白的主要特性，以及它在各种细胞类型中的表达情况和一些检测方法。
