Amin Shilu, Parker Anton, Mann Jelena
Cell Signalling, Institute of Cellular Medicine, 4th Floor Catherine Cookson Building, University of Newcastle, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom.
Int J Biochem Cell Biol. 2008;40(9):1654-8. doi: 10.1016/j.biocel.2007.05.016. Epub 2007 May 31.
The protein tyrosine kinase zeta-chain associated protein kinase (ZAP70), normally expressed in T cells and a subset of B cells, is solely expressed in poor prognosis chronic lymphocytic leukaemia and implicated in enhanced B cell receptor signalling. As a result, the expression of this protein provides an ideal prognostic marker for the disease. A previous study has shown differential CpG methylation of a 5' region of ZAP70 in leukaemic lymphoid cells, although no further epigenetic studies have been reported. Further investigation into the expression of ZAP70 may therefore provide targets for therapies.
蛋白酪氨酸激酶ζ链相关蛋白激酶（ZAP70）通常在T细胞和一部分B细胞中表达，而仅在预后不良的慢性淋巴细胞白血病中表达，并与增强的B细胞受体信号传导有关。因此，这种蛋白质的表达为该疾病提供了理想的预后标志物。先前的一项研究表明，白血病淋巴样细胞中ZAP70 5'区域存在差异CpG甲基化，尽管尚未有进一步的表观遗传学研究报道。因此，对ZAP70表达的进一步研究可能会为治疗提供靶点。
