全合成在神经退行性疾病问题中的应用：一路走来的迷人化学。

Applications of total synthesis to problems in neurodegeneration: Fascinating chemistry along the way.

作者信息

Wilson Rebecca M, Danishefsky Samuel J

机构信息

Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10021, USA.

出版信息

Acc Chem Res. 2006 Aug;39(8):539-49. doi: 10.1021/ar068018n.

DOI:10.1021/ar068018n

PMID:16906750

Abstract

The possibility for the application of organic synthesis to the discovery of new agents in combating neurodegenerative disorders is described. Our focus has been on agents derived from natural-product leads and natural products themselves prepared through total synthesis. Herein, we describe some of the chemistry as well as interesting observations made along the way.

摘要

本文描述了有机合成应用于发现对抗神经退行性疾病新药物的可能性。我们关注的重点是源自天然产物先导化合物以及通过全合成制备的天然产物本身的药物。在此，我们描述了一些相关化学内容以及在此过程中所做的有趣观察。