Campàs O, Kafri Y, Zeldovich K B, Casademunt J, Joanny J-F
Institut Curie, UMR CNRS 168, 26 rue d'Ulm 75248 Paris Cedex 05, France.
Phys Rev Lett. 2006 Jul 21;97(3):038101. doi: 10.1103/PhysRevLett.97.038101. Epub 2006 Jul 19.
The collective dynamics of N interacting processive molecular motors are considered theoretically when an external force is applied to the leading motor. We show, using a discrete lattice model, that the force-velocity curves strongly depend on the effective dynamic interactions between motors and differ significantly from those of a simple approach where the motors equally share the force. Moreover, they become essentially independent of the number of motors if N is large enough (N> or approximately 5 for conventional kinesin). We show that a two-state ratchet model has a very similar behavior to that of the coarse-grained lattice model with effective interactions. The general picture is unaffected by motor attachment and detachment events.
当外力作用于领头的分子马达时，从理论上考虑了N个相互作用的前进分子马达的集体动力学。我们使用离散晶格模型表明，力-速度曲线强烈依赖于马达之间的有效动态相互作用，并且与马达平均分担力的简单方法有显著差异。此外，如果N足够大（对于传统驱动蛋白，N>或约为5），它们基本上与马达数量无关。我们表明，双态棘轮模型与具有有效相互作用的粗粒化晶格模型具有非常相似的行为。一般情况不受马达附着和脱离事件的影响。
