Bennett K, Feely J, Thornton O, Dobson M, O'Morain C A, O'Connor H J
Department of Pharmacology and Therapeutics, Trinity Centre for Health Sciences, St James Hospital, Dublin, Ireland.
Aliment Pharmacol Ther. 2006 Aug 15;24(4):637-41. doi: 10.1111/j.1365-2036.2006.03027.x.
It is unclear what impact Helicobacter pylori infection has had on the management of dyspepsia in primary care and to what extent published guidelines on H. pylori are implemented in routine clinical practice.
To assess the impact of H. pylori infection on the management of dyspepsia in primary care.
Patients referred by primary care doctors to an open-access 13-carbon urea breath test service over a 2-year period for their first urea breath test were included in the study. Individual breath results were linked with data on prescribing obtained from the General Medical Services prescription database.
Of 805 patients, 374 (47%) had a positive urea breath test and 431 (54%) a negative urea breath test. Of positive urea breath test patients, only 245 (64%) were prescribed eradication therapy in the 3 months after the breath test and only 43% were referred back for re-testing. In the year after the urea breath test, there was a significant fall in prescribing of antisecretory therapy which was greatest in the patients who received H. pylori therapy (P < 0.001).
There appears to be under and inappropriate treatment of H. pylori infection in primary care, and a low rate of re-testing after eradication, indicating that current guidelines are not well implemented in practice.
目前尚不清楚幽门螺杆菌感染对基层医疗中消化不良的管理有何影响,以及已发表的幽门螺杆菌指南在常规临床实践中的实施程度。
评估幽门螺杆菌感染对基层医疗中消化不良管理的影响。
本研究纳入了在两年期间由基层医疗医生转介至开放式13碳尿素呼气试验服务进行首次尿素呼气试验的患者。个体呼气结果与从全科医疗服务处方数据库获得的处方数据相关联。
805例患者中,374例(47%)尿素呼气试验呈阳性,431例(54%)呈阴性。在尿素呼气试验呈阳性的患者中,只有245例(64%)在呼气试验后的3个月内接受了根除治疗,只有43%的患者被转回进行重新检测。在尿素呼气试验后的一年中,抗分泌治疗的处方量显著下降,在接受幽门螺杆菌治疗的患者中下降最为明显(P < 0.001)。
基层医疗中幽门螺杆菌感染的治疗似乎不足且不恰当,根除治疗后的重新检测率较低,这表明当前指南在实践中并未得到很好的实施。