与白细胞介素2受体的三条链结合的白细胞介素2的结构以及信号传导是如何发生的。
The structure of IL2 bound to the three chains of the IL2 receptor and how signaling occurs.
作者信息
Smith Kendall A
机构信息
The Division of Immunology, Department of Medicine, Weill Medical College, Cornell University, New York, NY 10021, USA.
出版信息
Med Immunol. 2006 Aug 14;5:3. doi: 10.1186/1476-9433-5-3.
Abstract
The interleukin-2 molecule and receptor were the first of the interleukins to be discovered and characterized at the molecular level. Now after 20 years of effort, two groups have succeeded in determining the structure of IL2 bound to the external domains of the three receptor chains in a quaternary complex. What do we know now that we did not know before this structural information was available, and how do these new data help us to develop new therapies?
摘要
白细胞介素-2分子及其受体是首批在分子水平上被发现和表征的白细胞介素。经过20年的努力，现在有两个研究小组成功确定了白细胞介素-2与三元复合物中三条受体链的胞外结构域结合时的结构。在获得这些结构信息之前我们所不知道的事情，现在我们了解了哪些？这些新数据又如何帮助我们开发新的治疗方法？
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