Sigalov Alexander B
Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA.
Trends Pharmacol Sci. 2006 Oct;27(10):518-24. doi: 10.1016/j.tips.2006.08.004. Epub 2006 Aug 14.
Multichain immune recognition receptors (MIRRs) represent a family of surface receptors that is expressed on different cells and that transduces extracellular signals, leading to many biological responses. The most intriguing common structural feature of MIRR family members is that the extracellular recognition domains and the intracellular signaling domains are located on separate subunits. It is not clear how extracellular ligand binding triggers MIRRs and initiates intracellular signal-transduction processes. In this article, I suggest that the structural similarity of the MIRRs provides the basis for the similarity in the mechanisms of MIRR-mediated transmembrane signaling. This hypothesis assumes that the therapeutic strategies learned from a novel mechanistic model of MIRR-mediated signal transduction, the signaling chain homo-oligomerization model, are generalized for this entire family and have important implications for the treatment of many disorders that are mediated by immune cells, including HIV.
多链免疫识别受体（MIRRs）代表一类表面受体家族，其在不同细胞上表达并转导细胞外信号，从而引发多种生物学反应。MIRR家族成员最引人关注的共同结构特征是，细胞外识别结构域和细胞内信号传导结构域位于不同的亚基上。目前尚不清楚细胞外配体结合如何触发MIRRs并启动细胞内信号转导过程。在本文中，我认为MIRRs的结构相似性为MIRR介导的跨膜信号传导机制的相似性提供了基础。这一假设认为，从MIRR介导的信号转导新机制模型——信号链同源寡聚化模型中学到的治疗策略，可推广至整个家族，并对治疗包括HIV在内的许多由免疫细胞介导的疾病具有重要意义。
